Results in newborns and premature babies
| PT (n = 11) |
PTT (n = 13) |
FT (n = 12) |
P (ANOVA, PT vs PTT vs FT) |
P (ANOVA, PT vs PTT) |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Absolute Units (cm3) | Relative to ICV (%) | Absolute Units (cm3) | Relative to ICV (%) | Absolute Units (cm3) | Relative to ICV (%) | P Absolute Units | P Relative to ICV | P Absolute Units | P Relative to ICV | |
| ICV | 269.8 ± 36.5 | 431.7 ± 70.0 | 427.4 ± 53.8 | F = 31.0P < .001 | F = 47.6 P < .001 | |||||
| Total brain volume | 246.5 ± 32.3 | 391 ± 66.1 | 395 ± 49.2 | F = 30.2 P < .001 | F = 43.5 P < .001 | |||||
| CGM | 83.5 ± 22.2 | 30.6 ± 5.1 | 179 ± 41.5 | 41.0 ± 5.4 | 181.4 ± 29.3 | 42.4 ± 4.1 | F = 33.6 P < .001 | F = 23.1 P < .001 | F = 46.6 P < .001 | F = 23.1 P < .001 |
| UMWM | 142.4 ± 15.0 | 53.1 ± 4.8 | 185.3 ± 30.8 | 43.2 ± 5.1 | 183.4 ± 27.4 | 43.0 ± 4.4 | F = 10.1 P < .001 | F = 16.8 P < .001 | F = 17.6 P < .001 | F = 23.7 P < .001 |
| MWM | 6.1 ± 1.8 | 2.2 ± 0.5 | 10.7 ± 3.0 | 2.5 ± 0.8 | 10.72 ± 4.63 | 2.5 ± 1.0 | F = 7.0 P = .003 | F = 0.4 P > .1 | F = 18.8 P < .001 | F = 1.0 P > .1 |
| BG | 14.2 ± 4.2 | 5.4 ± 1.7 | 15.7 ± 5.7 | 3.7 ± 1.1 | 17.14 ± 4.39 | 4.0 ± 0.9 | F = 1.0 P > .1 | F = 5.8 P = .007 | F = 0.5 P > .1 | F = 8.6 P = .008 |
| CSF | 23.3 ± 9.6 | 8.6 ± 3.0 | 40.7 ± 21.2 | 9.5 ± 4.3 | 32.4 ± 11.0 | 7.5 ± 2.3 | F = 3.8 P = .03 | F = 1.0 P > .1 | F = 6.2 P = .02 | F = 0.4 P > .1 |
Note:—Fifteen premature babies had 2 MRIs, one after birth (PT) and one at 40 wks (PTT); 12 newborns had an MRI at 40 wks (FT). ICV indicates intracranial volume; CGM, cortical gray matter; UMWM, ummyelinated white matter; MWM, myelinated white matter; BG, basal ganglia; CSF, cerebrospinal fluid.