Table 1.
Characteristics of colorectal carcinomas with or without CD47 expression. a, p-values were calculated by the Chi-square test for CD47 expression. b, t-test or c, Cochran–Armitage trend test was used to calculate p-values. The Bonferroni-corrected p-value for significance was p ≈ 0.0042 (0.05/12).
| Total No. | CD47 Positive | CD47 Negative | p-Value | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 269 | (100%) | 95 | (35%) | 174 | (65%) | ||||
| Sex | a | ||||||||
| Male | 143 | (53%) | 56 | (59%) | 87 | (50%) | 0.20 | ||
| Female | 126 | (47%) | 39 | (41%) | 87 | (50%) | |||
| Age, years (mean ± S.D.) | 68.6 ± 12.6 | 67.1 ± 14.6 | 69.4 ± 11.3 | 0.15 | b | ||||
| Size, cm (mean ± S.D.) | 5.0 ± 2.6 | 4.8 ± 2.4 | 5.1 ± 2.6 | 0.32 | b | ||||
| Tumor location | a | ||||||||
| Right-sided colon | 124 | (46%) | 42 | (44%) | 82 | (47%) | 0.89 | ||
| Left-sided colon | 86 | (32%) | 31 | (33%) | 55 | (32%) | |||
| Rectum | 59 | (22%) | 22 | (23%) | 37 | (21%) | |||
| pT stage | c | ||||||||
| pT2 | 36 | (13%) | 17 | (18%) | 19 | (11%) | 0.50 | ||
| pT3 | 189 | (70%) | 61 | (64%) | 128 | (74%) | |||
| pT4 | 44 | (16%) | 17 | (18%) | 27 | (15%) | |||
| Histological differentiation | a | ||||||||
| Well to moderately | 242 | (90%) | 80 | (84%) | 162 | (93%) | 0.032 | ||
| Poorly | 27 | (10%) | 15 | (16%) | 12 | (7%) | |||
| Mucus production | a | ||||||||
| Positive | 14 | (5%) | 9 | (9%) | 5 | (3%) | 0.040 | ||
| Negative | 255 | (95%) | 86 | (91%) | 163 | (97%) | |||
| Lymph node metastasis | a | ||||||||
| Positive | 124 | (49%) | 52 | (58%) | 72 | (44%) | 0.049 | ||
| Negative | 129 | (51%) | 38 | (42%) | 91 | (56%) | |||
| Peritoneal metastasis | a | ||||||||
| Positive | 50 | (19%) | 18 | (19%) | 32 | (18%) | 1 | ||
| Negative | 219 | (81%) | 77 | (81%) | 142 | (82%) | |||
| Distant organ metastasis | a | ||||||||
| Positive | 44 | (16%) | 17 | (18%) | 27 | (16%) | 0.61 | ||
| Negative | 225 | (84%) | 78 | (82%) | 147 | (84%) | |||
| Operation status | a | ||||||||
| Complete resection | 237 | (88%) | 85 | (89%) | 152 | (87%) | 0.70 | ||
| Incomplete resection | 32 | (12%) | 10 | (11%) | 22 | (13%) | |||
| MMR system status | a | ||||||||
| Deficient | 31 | (12%) | 14 | (15%) | 17 | (10%) | 0.24 | ||
| Preserved | 238 | (88%) | 81 | (85%) | 157 | (90%) | |||