Fig 5.

Graph shows apparent diffusion coefficient (ADC) value change in the frontal and parietal white matter. Abscissa indicates days after onset. Intravenous immunoglobulin therapy was performed on day 5. ADC value decrease in parietal lobe is more distinct in the deep white matter (DWM) than in the superficial white matter (SWM). This remarkable ADC value decrease is transient and recovers to a normal value at day 16 from onset (11 days after intravenous immunoglobulin therapy). The frontal DWM in which no abnormal high signal intensity is recognized on diffusion-weighted MR images also shows transient ADC value decrease.