TABLE 4:

Statistically significant lowest cutoff rCBV_T values tested for different mean differences

Parameter	Cutoff rCBVT Values
	For Grading*			For Differentiation†
	3.9a	2.6b	4.3c	2.3d	3.9e	2.3f	3.9g	3.9h	2.2i	2.3j	3.9k	3.9l	2.3m	2.2n	2.5o
ROC area	0.936	1.000	0.917	0.804	0.918	0.929	0.908	0.941	0.921	0.935	0.941	0.896	0.875	0.867	0.875
SE	0.037	0.000	0.068	0.061	0.053	0.047	0.060	0.049	0.065	0.052	0.052	0.069	0.072	0.085	0.079
AS	0.000	0.000	0.003	0.000	0.000	0.000	0.000	0.001	0.000	0.000	0.007	0.000	0.000	0.004	0.001
Sensitivity	95.46	100	100	94.12	90.91	94.12	95.46	100	94.12	94.12	100	90.91	83.33	83.33	75.00
Specificity	91.67	100	83.33	66.67	88.24	66.67	88.24	88.24	90.00	92.86	88.24	88.24	91.67	90.00	100
PPV	87.50	100	77.78	57.14	90.91	57.14	91.30	77.78	94.12	94.12	66.67	83.33	83.33	90.91	100
NPV	97.06	100	100	96.00	88.24	96.00	93.75	100	90.00	92.86	100	93.75	91.67	81.82	82.35
Accuracy	93.10	100	89.47	75.47	89.74	75.47	92.31	91.67	92.59	93.55	90.48	89.29	88.89	86.36	88.46

Note.—rCBV_T indicates tumoral relative cerebral blood volume; ROC, area under curve; SE, standard error; AS, asymptotic significance; PPV, positive predictive value; NPV, negative predictive value.

^*Superscripts indicate:

^aLow- and high-grade glial tumors;

^blow- and high-grade astrocytic gliomas;

^clow- and high-grade non-astrocytic gliomas.

^†Superscripts indicate:

^dLow-grade glial tumors from metastases

^ehigh-grade glial tumors from metastases;

^flow-grade astrocytomas from metastases;

^ghigh-grade astrocytomas from metastases;

^hhigh-grade non-astrocytic gliomas from metastases;

ⁱpilocytic astrocytomas from metastases;

^jdiffuse astrocytomas from metastases;

^kanaplastic astrocytomas from metastases;

^lglioblastoma multiforme from metastases;

^mlow-grade astrocytomas from low-grade oligodendrogliomas;

ⁿpilocytic astrocytomas from low-grade oligodendrogliomas;

^odiffuse astrocytomas from low-grade oligodendrogliomas.