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. 2005 Nov;26(10):2446–2454.

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Fig 1. — Histologic preparations of low-grade PCNSLs (patient 9; lymphoplasmacellular lymphoma), opposed to high-grade PCNSLs. A, Infiltrates of small, mature lymphocytes surrounded by amorphous substance (immunohistologic demonstration of light-chain deposits) and absence of blastic, immature cells (hematoxylin and eosin; original magnification ×400). The lymphocytes are positive for the B-cell antigen CD20 and show a predominant expression of the immunoglobulin light chain lambda, indicating monoclonality (not shown). B, Typical appearance of high-grade PCNSL, composed of immature blasts with large and partly bean-shaped nuclei and prominent nucleoli (hematoxylin and eosin; original magnification ×400). C, Lymphoma cells of low-grade PCNSL demonstrate a low growth fraction of only 2% (Ki-67 antibody; original magnification ×200). D, High-grade PCNSL with a typical high growth fraction of 95% (MIB-1 antibody; original magnification ×400). Note.—Reproduced from K. Jahnke et al, Br J Haematol 2005;128:616–624 (© British Society for Haematology).