Table 2. Absolute risk of death by 28 days, SARS-CoV-2 VOC vs non-VOC infection, England, 16 November 2020–5 February (n =112,979).

Sex	Age group (years)	Non-VOC		VOC
		%	95% CI	%	95% CI
No comorbidities
Female n = 52,718	0– < 65	0.05	0.03–0.06	0.07	0.06–0.09
	65– < 75	0.45	0.30–0.59	0.72	0.50–0.95
	75– < 85	1.08	0.71–1.45	1.73	1.15–2.31
	≥ 85	2.36	1.47–3.25	3.75	2.34–5.16
Male n = 42,724	0– < 65	0.09	0.07–0.11	0.14	0.11–0.17
	65– < 75	0.85	0.59–1.12	1.37	0.96–1.77
	75– < 85	2.03	1.35–2.71	3.24	2.19–4.30
	≥ 85	4.38	2.72–6.03	6.87	4.33–9.42
One comorbidity
Female n = 6,858	0– < 65	0.11	0.08–0.15	0.18	0.13–0.24
	65– < 75	1.09	0.78–1.41	1.75	1.25–2.25
	75– < 85	2.60	1.84–3.35	4.13	2.94–5.32
	≥ 85	5.54	3.77–7.31	8.64	5.91–11.38
Male n = 6,661	0– < 65	0.22	0.15–0.28	0.35	0.25–0.45
	65– < 75	2.06	1.51–2.62	3.29	2.44–4.14
	75– < 85	4.81	3.48–6.14	7.54	5.52–9.55
	≥ 85	9.94	6.87–13.01	15.10	10.63–19.58
Two or more comorbidities
Female n = 1,921	0– < 65	0.21	0.14–0.28	0.34	0.22–0.45
	65– < 75	1.99	1.41–2.57	3.18	2.27–4.09
	75– < 85	4.66	3.45–5.87	7.31	5.42–9.20
	≥ 85	9.65	7.01–12.29	14.68	10.73–18.63
Male n = 2,097	0– < 65	0.40	0.27–0.52	0.64	0.44–0.84
	65– < 75	3.72	2.74–4.69	5.87	4.38–7.35
	75– < 85	8.44	6.44–10.44	12.93	9.99–15.87
	≥ 85	16.65	12.42–20.88	24.34	18.55–30.13

Absolute risk is calculated from the marginal means of a fully adjusted logistic regression model with outcome death by 28 days after positive test for SARS-CoV-2, restricted to the population with a minimum of 28 days from testing to the follow-up censor. Deaths beyond 28 days were censored. The fully adjusted model includes adjustment for: age, sex, index of multiple deprivation, ethnicity, smoking status, obesity, household size, NHS England region, rural/urban classification, comorbidities, epidemiological week and care home status.