Figure 1. NORAD and HCG11 presented different expression patterns in BC subtypes. (A) Analyzing TCGA cohort on luminal A (n = 231) and basal-like (n = 98) subtypes, NORAD was upregulated in Luminal A while HCG11 was upregulated in basal-like subtype. (B) Relative expression measured by RT-qPCR on luminal A (n = 21) and triple-negative (n = 23) Brazilian BC samples, NORAD and HCG11 maintained the pattern of expression observed in TCGA cohort. (C) TCGA cohort data for promoter methylation. HCG11 presented in Luminal A subtype greater promoter methylation. (D) TCGA cohort data for promoter accessibility was performed by assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq). HCG11 exhibited a more accessible promoter in Basal-like subtype. * p < 0.05; ** p < 0.01; *** p < 0.001; N.S - Not Significative.