Table 3.
Hub node genes in the protein-protein interaction network identified with filtering node degree ≥10
| Number | Genes | Degree | MCODE Cluster | MCODE Node Status |
|---|---|---|---|---|
| 1 | VEGFA | 24 | Module 1 | Seed |
| 2 | IGF1 | 21 | Module 1 | Clustered |
| 3 | EGF | 20 | Module 1 | Clustered |
| 4 | FN1 | 20 | Module 1 | Clustered |
| 5 | TGFB1 | 19 | Module 1 | Clustered |
| 6 | KNG1 | 19 | Module 1 | Clustered |
| 7 | TIMP1 | 18 | Module 1 | Clustered |
| 8 | TGFB3 | 17 | Module 1 | Clustered |
| 9 | AKT1 | 16 | -- | Unclustered |
| 10 | TGFB2 | 16 | Module 1 | Clustered |
| 11 | IGF2 | 16 | Module 1 | Clustered |
| 12 | SERPINE1 | 15 | Module 1 | Clustered |
| 13 | THBS1 | 15 | Module 1 | Clustered |
| 14 | MAPK3 | 15 | -- | Unclustered |
| 15 | EGFR | 14 | -- | Unclustered |
| 16 | CTNNB1 | 13 | -- | Unclustered |
| 17 | MMP2 | 13 | Module 2 | Clustered |
| 18 | VWF | 13 | Module 1 | Clustered |
| 19 | MMP9 | 12 | Module 3 | Clustered |
| 20 | DCN | 11 | Module 2 | Seed |
| 21 | CDH1 | 10 | -- | Unclustered |
| 22 | EDN1 | 10 | -- | Unclustered |