Table 5.
Details of the 26 drugs that potentially target 11 of the 13 core genes
| Number | Drug | Genes | Interaction | Score | Drug Class | Approved? | Reference (PubMed ID) |
|---|---|---|---|---|---|---|---|
| 1 | Ranibizumab** | VEGFA | inhibitor | 14 | antineoplastic agents, ocular vascular disorder agents | Yes* | 18046235 |
| 2 | Bevacizumab | VEGFA | inhibitor | 10 | antineoplastic agent, immunomodulating agents | Yes* | 15705858 |
| 3 | Aflibercept** | VEGFA | inhibitor | 7 | antineoplastic agent, ocular vascular disorder agents | Yes* | 22813448 |
| 4 | Carvedilol | VEGFA | other | 5 | vasodilator agents, neurotransmitter agents | Yes* | 15071347 |
| 5 | Dalteparin sodium | VEGFA | inhibitor | 4 | hematologic agents, fibrinolytic agents | Yes | 21091776 |
| 6 | Phenytoin | VEGFA | N/A | 2 | anticonvulsants | Yes* | 15458527 |
| 7 | Vandetanib | VEGFA | inhibitor | 1 | antineoplastic and immunomodulating agent | Yes* | None found |
| 8 | Dusigitumab | IGF1 | inhibitor | 1 | not available | No | None found |
| 9 | Sucralfate | EGF | inducer | 4 | antiulcer agent, antimuscarinics | Yes* | 8578218 |
| 10 | Ocriplasmin** | FN1 | cleavage | 3 | not available | Yes | 23193358 |
| 11 | AS-1409 | FN1 | binder | 2 | antineoplastic agent | No | None found |
| 12 | L19TNFa | FN1 | N/A | 1 | fibronectin binding agent | No | None found |
| 13 | Urokinase | SERPINE1 | N/A | 7 | thrombolytic agents, fibrinolytic agents | Yes* | 12709915 |
| 14 | Troglitazone | SERPINE1 | antagonist | 6 | hypoglycemic agents | No | 10871202 |
| 15 | Drotrecogin alfa | SERPINE1 | N/A | 5 | antithrombotic agents, fibrinolytic agents, | Yes* | 12004248 |
| 16 | Hydrochlorothiazide | KNG1 | inhibitor | 1 | antihypertensive agents, hypotensive agents | Yes* | None found |
| 17 | Tretinoin | THBS1 | N/A | 3 | antineoplastic agents, dermatologic agents, immunosuppressive agents | Yes* | 9447832 |
| 18 | Corticotropin | THBS1 | N/A | 2 | immunosuppressive agents | Yes* | 8698834 |
| 19 | Camptothecin | THBS1 | N/A | 2 | antineoplastic agents | Yes* | 16962673 |
| 20 | Caplacizumab | VWF | inhibitor | 3 | antithrombotic | No | None found |
| 21 | Streptozotocin | VWF | inhibitor | 3 | antibiotics, antineoplastic agents, immunosuppressive agents | Yes* | 16422885 |
| 22 | Thalidomide | VWF | N/A | 2 | antineoplastic agents | Yes* | 12871448 |
| 23 | Hyaluronidase | TGFB1 | inhibitor | 5 | not available | Yes* | 9435505 |
| 24 | Vitamin E | TGFB1 | N/A | 3 | antioxidants | Yes* | 1505665 |
| 25 | Lerdelimumab | TGFB2 | inhibitor | 2 | monoclonal antibody | No | None found |
| 26 | Fresolimumab | TGFB1, TGFB2, TGFB3 | inhibitor | 2 | antineoplastic agents | No | None found |
**Drugs that have been used to treat ophthalmic disease.
*Drugs that have been approved by the US Food and Drug Administration.