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. 2021 Feb 6;18(7):1687–1698. doi: 10.7150/ijms.53603

Figure 4.

Figure 4

QDG attenuates neuronal apoptosis and loss in rats after MCAO/R surgery and in HT22 cells after OGD/R. (A) Representative images of apoptosis in the cerebral cortex area are presented at a magnification of 40× using TUNEL staining. (B) Representative images of NeuN-positive neurons in the cerebral cortex area are presented at a magnification of 40× using IHC analysis. (C) Representative images of HT22 cells apoptosis are presented at a magnification of 20× using Hoechst 33258 staining. (D) The corresponding quantification of apoptosis in the cerebral cortex area was determined by TUNEL staining. (E) The corresponding quantification of NeuN immunoreactivity was determined by IHC analysis. (F) The corresponding quantification of HT22 cells apoptosis was determined by Hoechst 33258 staining. *p<0.05 compared to sham group; Δp<0.05, compared to model group; *p<0.05, compared to control group; Δp<0.05, compared to OGD/R group.