Table 2.
First laboratory findings of COVID-19 patients within 3 days of admission among normal, overweight and obesity group
| Normal (n=242) | Overweight (n=179) | Obesity (n=42) | |
|---|---|---|---|
| Blood routine A | |||
| White blood cell count, ×109/L | 4.88 (3.81, 6.49) | 5.76 (4.42, 7.2)* | 6.49 (4.27, 7.79)* |
| Neutrophil percentage, % | 66.1 (56.2, 75.8) | 68.7 (60.9, 79.3)* | 71.7 (62.4, 79.0) |
| Neutrophil count, ×109/L | 3.23 (2.31, 4.63) | 3.91 (2.7, 5.38)* | 4.34 (2.74, 6.32)* |
| Lymphocyte percentage, % | 23.3 (15.4, 31.8) | 19.6 (12.3, 28.3)* | 20.2 (13.4, 28.7) |
| Lymphocyte count, ×109/L | 1.08 (0.81, 1.46) | 1.12 (0.79, 1.53) | 1.12 (0.89, 1.65) |
| Monocyte percentage, % | 8.6 (6.3, 10.9) | 8.5 (6.1, 10.4) | 7.6 (5.3, 8.7)* |
| Monocyte count, ×109/L | 0.42 (0.31, 0.56) | 0.45 (0.35, 0.61) | 0.45 (0.34, 0.57) |
| Basophil count, ×109/L | 0.01 (0.01, 0.02) | 0.01 (0.01, 0.03)* | 0.02 (0.01, 0.03)* |
| Eosinophil count, ×109/L | 0.01 (0, 0.06) | 0.03 (0, 0.08) | 0.01 (0, 0.09) |
| Blood platelet count, ×109/L | 214 (160, 273) | 230 (185, 286)* | 230 (168, 308) |
| Inflammation | |||
| C-reactive protein B, mg/L | 33.1 (6.35, 70.15) | 27 (6.65, 60.85) | 41.65 (9.28, 70.5) |
| hsC-reactive protein C, mg/L | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) |
| Procalcitonin D, ng/mL | 0.046 (0.028, 0.096) | 0.051 (0.036, 0.082) | 0.06 (0.04, 0.08) |
| Intravenous glucose E, mmol/L | 5.33 (4.79, 6.61) | 5.76 (5.1, 7.79)* | 6.29 (5.13, 7.15) |
| Blood lipid F | |||
| Total cholesterol, mmol/L | 3.8 (3.26, 4.47) | 3.75 (3.33, 4.43) | 3.85 (3.33, 4.40) |
| Triglyceride, mmol/L | 1.14 (0.9, 1.52) | 1.19 (0.97, 1.68) | 1.34 (1.09, 2.16)* |
| Low density lipoprotein, mmol/L | 2.27 (1.85, 2.91) | 2.45 (1.94, 2.88) | 2.46 (2.01, 2.97) |
| High density lipoprotein, mmol/L | 0.97 (0.81, 1.14) | 0.87 (0.77, 1.05)* | 0.88 (0.72, 1.01)* |
| Blood electrolyte F | |||
| K+ | 3.9 (3.6, 4.4) | 3.9(3.6, 4.2) | 4.0 (3.6, 4.3) |
| Na+ | 141 (138, 144) | 141 (138, 144) | 141 (137, 144) |
| Liver function | |||
| Alanine aminotransferase G, U/L | 20 (15, 32) | 31 (20, 54)* | 33 (21, 47)* |
| Aspartate aminotransferase G, U/L | 24 (19, 34) | 29 (21, 43)* | 30 (22, 42) |
| γ-glutamyltransferase H, U/L | 22 (15, 35) | 33 (22, 57)* | 43 (25, 64)* |
| Alkaline phosphatase H, U/L | 59 (49, 70) | 64 (54, 79)* | 65 (54, 84) |
| Total bilirubin H, μmol/L | 9.8 (7.6, 12.6) | 10.8(8.1, 14.2)* | 11.2(8.8, 14.8) |
| Direct bilirubin H, μmol/L | 3.5 (2.5, 4.8) | 3.9 (2.9, 5)* | 4.2 (2.9, 5.4) |
| Kidney Function I | |||
| Creatinine, μmol/L | 60 (49, 72) | 61 (50, 72) | 65 (50, 76) |
| Blood urea nitrogen, mmol/L | 4.29 (3.41, 5.59) | 4.4 (3.58, 5.59) | 4.5 (3.95, 5.72) |
| Blood uric acid, μmol/L | 232 (187, 298) | 253 (211, 319)* | 305 (231, 357)*# |
| eGFR, mL/min | 98.4 (90.0, 106.9) | 98.9 (92.0, 108.3) | 97.3 (85.6, 112.1) |
| Myocardial injury | |||
| Creatine kinase J, ng/mL | 57 (37, 87) | 59 (39, 106) | 64 (42, 115) |
| Creatine kinase-MB K, ng/mL | 0.89 (0.54, 1.35) | 0.96 (0.66, 1.26) | 1.12 (0.76, 2.2)* |
| Lactate dehydrogenase L, U/L | 252 (203, 310) | 268 (217, 340)* | 286 (208, 356) |
| Myoglobin M, g/L | 36.54 (25.26, 58.8) | 40.03 (27.92, 61.3) | 45.04 (30.57, 80.48) |
| Hypersensitive troponin I N, ng/mL | 0.006 (0.006, 0.009) | 0.006 (0.006, 0.008) | 0.006 (0.006, 0.009) |
| NTpro-BNP O, pg/ml | 114.7 (47.3, 235.2) | 105.1 (34.6, 235.3) | 152.7 (61.5, 370.1) |
| Coagulation function P | |||
| D-Dimer, mg/L | 0.62 (0.36, 1.44) | 0.63 (0.38, 1.36) | 0.72 (0.4, 2.67) |
| Prothrombin time activity, % | 84.7 (75.9, 95) | 84.7 (77.3, 93.3) | 85.4 (82.2, 91.4) |
| APTT, sec | 28.3 (26.3, 31.3) | 27.8 (25.6, 30.2)* | 27.7 (25.5, 31.2) |
| International normalized ratio | 1.03 (0.97, 1.08) | 1.03 (0.97, 1.07) | 1.03 (0.99, 1.05) |
| Thrombin time, sec | 17.6 (16.7, 18.4) | 17.6 (16.6, 18.5) | 17.4 (16.8, 18.2) |
| Prothrombin time, sec | 12 (11.4, 12.6) | 11.95 (11.425, 12.5) | 12 (11.6, 12.2) |
| Antithrombin III activity, % | 89.9 (82.2,97.8) | 88.8 (81.6, 97.8) | 87.6 (82.1, 95.9) |
| Fibrin degradation products, mg/L | 2.28 (0.94, 4.99) | 1.93 (0.98, 5.38) | 2.8 (1.81, 7.35) |
| Fibrinogen, g/L | 4.56 (3.42, 5.46) | 4.56 (3.73, 5.7) | 4.69 (3.52, 5.87) |
| Cellular immunity Q | |||
| CD16+56+ cell percentage, % | 13.1 (8.3, 21.5) | 12.5 (8.5, 18.8) | 16.4 (10.1, 21.3) |
| CD16+56+ cell counts, /μL | 119 (71, 180) | 117 (77, 175) | 159 (104, 193) |
| CD19+ cell percentage, % | 14.7 (11.0, 19.3) | 17.5 (13.2, 21.6)* | 19.1(15.2, 21.3)* |
| CD19+ cell counts, /μL | 129 (9, 184) | 159 (106, 247)* | 195 (124, 280)* |
| CD3+ cell percentage, % | 68.8 (58.1, 75.6) | 67.2 (58.0, 71.9) | 62.4 (53.4, 69.5)* |
| CD3+ cell counts, /μL | 623 (427, 882) | 659 (441, 927) | 628 (424, 858) |
| CD4+ cell percentage, % | 39.4 (32.0, 46.5) | 40.4 (33.8, 46.1) | 39.7 (33.4, 45.5) |
| CD4 cell counts, /μL | 375 (249, 513) | 420 (251, 576) | 359 (241, 535) |
| CD8+ cell percentage, % | 23.8 (17.2, 30.1) | 21.5 (16.5, 28.0) | 18.3 (14.0, 27.2) |
| CD8+ cell counts, /μL | 231 (128, 335) | 207 (132, 315) | 212 (114, 321) |
| CD4/CD8 ratio | 1.67 (1.21, 2.41) | 1.8 (1.32, 2.7) | 2.14 (1.38, 3.17) |
| Arterial blood gas analysis R | |||
| PH value | 7.42 (7.39, 7.46) | 7.43 (7.37, 7.46) | 7.44 (7.38, 7.46) |
| Partial pressure of oxygen, mmHg | 88 (70, 112) | 83 (70, 109) | 78 (55, 87) |
| Arterial oxygen saturation, % | 97 (94, 98) | 96 (94, 98) | 95 (90, 97) |
| Arterial lactate acid, mmol/L | 1.9 (1.5, 2.5) | 1.9 (1.4, 2.6) | 2.2 (1.6, 2.6) |
Values are Medium (IQR) unless stated otherwise. Continuous variables were compared by the Mann-Whitney test. * p<0.05 vs. Normal weight group; # p<0.05 vs. Overweight group. Abbreviation: hsC-reactive protein, high-sensitive reactive protein; eGFR, estimated glomerular filtration rate; NTpro-BNP, N-terminal pro-Brain Natriuretic Peptide; APTT, activated partial thromboplastin time. The total number of patients with available data in different groups (n1, n2 and n3 indicates the number in normal weight, overweight and obesity group, respectively): A: n1=237, n2=175, n3=42; B: n1=199, n2=155, n3=36; C: n1=202, n2=159, n3=36; D: n1=218, n2=170, n3=39; E: n1=238, n2=179, n3=42; F: n1=230, n2=173, n3=42; F: n1=238, n2=178, n3=41; G: n1=238, n2=179, n3=42; H: n1=232, n2=176, n3=42; I: n1=238, n2=179, n3=42; J: n1=232, n2=173, n3=41; K: n1=200, n2=140, n3=37; L: n1=232, n2=171, n3=41; M: n1=199, n2=140, n3=36; N: n1=201, n2=145, n3=36; O: n1=175, n2=130, n3=31; P: n1=215, n2=161, n3=39; Q: n1=198, n2=144, n3=33; R: n1=105, n2=82, n3=17.