Table 1.
Role of miRNAs in the development of certain types of cancer[24]
| Main characteristics of Cancer | Function | miRNAs |
|---|---|---|
| Insensitivity to stimulating and suppressing signals of growth | • Growth stimulation | • miR-21,-17 Cluster,-221,-222 |
| • Growth suppression | • miR-519,-146a,Let-7 | |
| Escape from programmed cell death (Apoptosis) | • Apoptosis stimulation | • miR-34Cluster,-29,-15,-10 |
| • Apoptosis suppression | • miR-290,-24,-34a | |
| Unlimited proliferation potential | • Immortality and aging control | • miR-290,-24,-34a |
| Angiogenesis induction | • Angiogenesis stimulation | • MiR-17-92Cluster,-378,-996,-27b,-130,-126,Let-7f |
| • Angiogenesis suppression | ||
| • miR-15,-16,-20a,-20b | ||
| Escape from immune system | • Escape from immune response | • miR-17-92Cluster,-155,-20a,-93,-106b,-372,-373,-520c |
| Metastasis | • Metastasis stimulation | • miR-10b,-21,-373,-520c,-155,--335,-206,-126,Let-7 |
| • Metastasis suppression | ||
| • miR-146a,-101,-200 | ||
| Genome instability | • Genome instability induction | • miR-16-1,-17,-20A,-15 |