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. 2021 Mar 19;11:179. doi: 10.1038/s41398-021-01287-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Umbilical cord monocyte-derived CB-iMGs. b Adult PBMC-derived iMGs. (i) Morphology by phase contrast; immunostained images of iMG cells stained with nuclei (Hoechst) and indicated microglial markers (ii) IBA1, (iii) CX3CR1, (iv) P2RY12, and (v) PU.1. Scale bar: 30 μm. c Quantitation of positively immunostained cells as a percentage of total cells (nuclei) for indicated microglial markers. Bars indicate mean of indicated no. of cells measured, error bars indicating SEM. d Quantitation of fold increase in gene expression of indicated microglial markers normalized to input (PBMCs and CB-MNCs, respectively) after iMG reprogramming, error bars indicating SEM (n = 3 measurements).