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. 2021 Mar 18;14:44. doi: 10.1186/s13045-021-01055-9

Table 2.

Responses seen in studies of 3L therapy

3L study Efficacy
A retrospective study of patients receiving 2L dasatinib or nilotinib after imatinib [55]

Significant correlation between higher rates of CCyR and DMR and no treatment interruption with ≤ 2L

5-year OS was 83.0% in total and 94.5% in patients with CML-CP

A report of patients treated with 3 sequential TKIs [27] Best response to 3L 2GTKI in 48 patients was MMR in 5 patients, CCyR in 3 patients, partial or minor CyR in 5 patients, and CHR in 6 patients
A report of patients treated with dasatinib or nilotinib after failing imatinib [57] Rates of MCyR, CCyR, and MMR were 50.0%, 34.6%, and 19.2%, respectively
A study of patients receiving 3L nilotinib or dasatinib [58]

CHR, MCyR, CyR, CCyR, and MMR rates were 31.7%, 7.3%, 14.6%, 17.1%, and 15.9%, respectively, with 14.6% having no response

Overall, 14% of patients died

A retrospective study of patients on 3L [52]

MCyR and CCyR were achieved in 15 of 45 and 11 of 52 patients, respectively

Overall, 13 patients died

A single-center study of nilotinib or dasatinib in patients who failed 2 prior TKIs [59]

CHR, CCyR, and MMR were achieved in 89%, 13%, and 24%, respectively, of patients with CML-CP

Of patients with CHR, 56% lost that response within a median of 23 months

5-year OS, PFS, and EFS were 86%, 54%, and 22%, respectively

2GTKI second-generation tyrosine kinase inhibitor, 2L second line, 3L third line, CCyR complete cytogenetic response, CHR complete hematologic response, CML-CP chronic myeloid leukemia in chronic phase, CyR cytogenetic response, DMR deep molecular response, EFS event-free survival, MCyR major cytogenetic response, MMR major molecular response, OS overall survival, PFS progression-free survival, TKI tyrosine kinase inhibitor