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. 2021 Mar 19;19:77. doi: 10.1186/s12951-021-00824-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — a Quantitative comparation of mPEG/HER-PGNSs internalized into SK-BR-3 cells with or without Her-2 antibody blocking; b Quantitative comparation of PGNSs, mPEG-PGNSs and mPEG/HER-PGNSs internalized into SK-BR-3 cells at 2, 4, 12, 24 h and 48 h using ICP-MS; c Quantitative comparation of PGNSs, DM1-mPEG-PGNSs and DM1-mPEG/HER-PGNSs internalized into MCF7 cells and d SK-BR-3 cells at 2, 4, 12, and 24 h using ICP-MS; and e TEM thin sections of cellular uptake of DM1-mPEG/HER-PGNSs in MCF7 cells and SK-BR-3 cells after 12 h (Scale bar = 500 nm, 100 nm); f k₀ and e k values for cellular uptake and elimination in SK-BR-3 cells and MCF-7 cells. (^*p < 0.05,^**p < 0.01,^***p < 0.001)