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. 2021 Mar 19;19:77. doi: 10.1186/s12951-021-00824-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — a In vivo CT imaging of orthotopic tumour-bearing mice before and 12 h after intravenous injection of iohexol, PGNSs, mPEG-PGNSs and mPEG/HER-PGNSs (red circles represent the tumour site); b CT values of the orthotopic tumour-bearing mice at different time points; c in vivo PA imaging of orthotopic tumour-bearing mice before and 2, 8, 24 h after intravenous injection of saline, PGNSs, mPEG-PGNSs and mPEG/HER-PGNSs (green arrows represent the PA signal); d PA intensity of the orthotopic tumour-bearing mice at different time points; e in vivo PT imaging with a NIR laser at 0, 1, 3 and 5 min of orthotopic tumour-bearing mice 24 h after intravenous injection of saline, PGNSs, mPEG-PGNSs and mPEG/HER-PGNSs (red circles represent the tumour site); and f temperature changes of the orthotopic tumour-bearing mice during NIR irradiation at different points. (^*p < 0.05, ^**p < 0.01, ^***p < 0.001)