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. 2021 Mar 19;19:52. doi: 10.1186/s12915-021-00991-9

Table 1.

Identification, validation, and function of 21 protein-coding genes in the B chromosomes from the studied species

A. scabripinnis A. paranae qPCR
Gene gFC qPCR SNPs gFC qPCR A. bockmanni A. fasciatus Function
amhr2 1.8 1 7 0.9 1 0 1 Gonadal development
bt1a1 1.7 1 0 − 0.4 1 0 0 Unknown
ccnd3 1.2 1 0 −0.1 0 0 0 Cell cycle
ccpg1 0.9 1 9 1.3 1 1 0 Cell cycle
cia30 7.0 1 0 7.9 1 1 1 Mitochondrial
g2e3 5.7 1 0 5.0 1 1 1 Cell cycle
hem2 1.8 1 3 0.9 1 1 0 Biosynthesis
lap4a 1.5 1 0 1.1 1 1 0 Transport
mdm2 2.0 1 0 1.9 1 0 1 Indirect cell cycle regulation
mot1 1.0 1 1 1.6 1 1 0 Transport
msh4 1.6 1 21 1.4 1 1 1 Cell cycle
nobox 1.7 1 5 3.1 1 1 0 Cell cycle
numa1 2.7 1 0 2.5 1 1 1 Cell cycle
nusap1 7.3 1 0 3.9 1 1 1 Cell cycle
rnf17 1.3 1 2 1.9 1 1 1 Indirect cell cycle regulation
sbno2 5.9 1 0 6.8 1 1 1 Transcriptional coregulator
sh3d21 1.5 1 34 1.6 1 1 1 Unknown
simc1 3.1 1 25 2.0 1 1 1 Transcription factor
slc5a8 1.0 1 5 1.6 1 0 0 Transport
tshb 0.7 1 2 1.7 1 0 0 Hormone-mediated signaling pathway
urok 0.4 0 0 2.3 1 0 0 Plasminogen activation
Sum 20 114 20 14 11

NGS analyses were performed for the large metacentric of A. scabripinnis and A. paranae, and, additionally, qPCR tests for their presence on B chromosomes in A. bockmanni and A. fasciatus. Genomic fold change (gFC) was calculated as log2(1B/0B) of mean nucleotide coverage along transcript length in the 1B and 0B libraries. In the qPCR columns, 1 indicates qPCR validation of gene overabundance in 1B genomes compared to 0B ones