TABLE 1:

Clinical features and serum levels of T₄, free T₃, and TSH before and after treatment

Patient	Initial Diagnosis*	Level Before Treatment			Clinical Diagnosis After Treatment	Clinical Assessment After Treatment‖	Level After Treatment
		T4 (nmol/L)†	T3 (pmol/L)‡	TSH (mU/L)§			T4 (nmol/L)†	T3 (pmol/L)‡	TSH (mU/L)§
1	Hyperthyroidism	284	32.2	<0.1	Euthyroidism	Symptoms remitted	116	7.8	<0.1
2	Hyperthyroidism	267	23+	<0.1	Euthyroidism	Symptoms remitted	61	2.2+	<0.1
3	Hyperthyroidism	263	13.2+	<0.1	Euthyroidism	Symptoms remitted	112	4.6+	<0.1
4	Hyperthyroidism	196	28.2	<0.1	Euthyroidism	Symptoms remitted	73	7.2	<0.1
5	Hyperthyroidism	142	11.1	<0.1	Euthyroidism	Symptoms remitted	53	2.8+	<0.1
6	Hyperthyroidism	287	39.7+	<0.1	Euthyroidism	Symptoms remitted	121	6.1+	1.4
7	Hyperthyroidism	>300	55.9	<0.1	Euthyroidism	Symptoms remitted	66	6.2	<0.1
8	Hyperthyroidism	307	>45	<0.1	Toxicity	Symptoms remitted	229	20.4	<0.1
9	Hypothyroidism	2	2.9	43.3	Euthyroidism	Symptoms remitted	81	6.9	2.5
10	Hypothyroidism	<15	NA	76.5	Euthyroidism	Symptoms remitted	94	NA	3.4
11	Hypothyroidism	<15	NA	>100	Euthyroidism	Symptoms remitted	113	NA	25.9

^*All patients with hyperthyroidism had neuropsychological symptoms of anxiety, agitation, restlessness, and hyperactivity. All patients with hypothyroidism had neuropsychological symptoms of tiredness, lethargy, mental slowing, and depression.

^†Normal range, 60–160 nmol/L.

^‡Normal ranges, 5.4–9.3 pmol/L (assay 1) and 2.5–5.3 pmol/L (assay 2) (denoted with +).

^§Normal range, 0.4–4.0 mU/L.

^‖In all patients, symptoms remitted at clinical assessment after treatment.