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Twenty-seven-year-old man diagnosed 18 years previously and treated with intrathecal MTX (total dose = 300 mg) and cranial radiation therapy (24 Gy). On coronal FLAIR image, there is grade 1 leukoencephalopathy (arrows), defined as patchy, mildly increased signal intensity in the periventricular white matter, without involvement of the subcortical U-fibers.
