Table 2:
Medulloblastoma | Anaplastic Astrocytoma/Astrocytoma | Pilocytic Astrocytoma | Anaplastic Ependymoma/Ependymoma | Choroid Plexus Papilloma | Choroid Plexus Carcinoma | Pineal Germinoma | All Tumors | |
---|---|---|---|---|---|---|---|---|
Subjects | 14 | 8 | 17 | 9 | 3 | 3 | 6 | 60 |
Absolute concentrations (mmol/kg tissue) | ||||||||
[NAA] | 0.9 ± 0.8 | 2.3 ± 1.5 | 1.9 ± 0.8 | 0.2 ± 0.4**** | 2.4 ± 1.3 | 0.2 ± 0.1***** | 1.3 ± 1.1 | 1.3 ± 1.1 |
[Cr] | 4.7 ± 1.7 | 6.2 ± 2.4 | 1.0 ± 0.8***** | 5.3 ± 3.1 | 1.3 ± 0.7* | 1.2 ± 0.7* | 3.1 ± 0.9 | 3.5 ± 2.6 |
[tCho] | 5.1 ± 1.5*** | 3.9 ± 3.1 | 2.2 ± 1.1* | 3.2 ± 1.5 | 1.8 ± 0.3*** | 5.1 ± 2.1 | 2.2 ± 0.5* | 3.4 ± 2.0 |
[mI] | 7.4 ± 4.0 | 12.3 ± 5.3 | 3.8 ± 2.1***** | 13.1 ± 5.7 | 20.4 ± 3.7* | 4.1 ± 2.0 | 5.2 ± 1.1* | 8.2 ± 5.8 |
[Gln] | 6.3 ± 3.5 | 9.51 ± 4.1 | 6.4 ± 3.2 | 8.4 ± 3.9 | 2.6 ± 0.6**** | 2.6 ± 1.5 | 4.4 ± 2.6 | 6.5 ± 3.7 |
[Glu] | 7.5 ± 4.0 | 4.8 ± 2.9 | 3.3 ± 1.8* | 2.9 ± 3.2 | 4.2 ± 2.4 | 2.7 ± 1.6 | 8.7 ± 2.7 | 5.0 ± 3.5 |
[Glx]† | 13.8 ± 5.2 | 14.4 ± 4.5 | 9.7 ± 3.5 | 11.3 ± 4.4 | 6.8 ± 2.0 | 5.4 ± 0.9**** | 13.1 ± 3.1 | 11.5 ± 4.7 |
[Tau] | 5.8 ± 2.3**** | 1.7 ± 1.1 | 0.4 ± 0.6***** | 1.5 ± 1.1 | 0.8 ± 0.9 | 2.5 ± 0.6 | 3.0 ± 1.3 | 2.3 ± 2.5 |
[Glc] | 1.0 ± 0.8 | 2.2 ± 1.1 | 2.5 ± 1.8 | 0.8 ± 0.7 | 1.6 ± 0.8 | 3.4 ± 2.6 | 0.9 ± 1.0 | 1.7 ± 1.5 |
[Lac] | 3.6 ± 1.6 | 2.8 ± 3.9 | 4.3 ± 2.2 | 2.1 ± 2.1 | 0.6 ± 0.5** | 1.5 ± 1.4 | 0.9 ± 1.6 | 3.0 ± 2.5 |
[sI] | 0.2 ± 0.2 | 0.5 ± 0.5 | 0.2 ± 0.3 | 0.3 ± 0.3 | 0.9 ± 0.2 | 0.0 ± 0.1*** | 0.3 ± 0.3 | 0.3 ± 0.3 |
[Ala] | 2.7 ± 1.2* | 0.9 ± 0.9 | 1.4 ± 0.7 | 1.7 ± 1.0 | 1.0 ± 0.7 | 0.9 ± 1.0 | 2.0 ± 0.9 | 1.7 ± 1.1 |
[Gua] | 3.7 ± 1.1* | 1.5 ± 0.5**** | 2.6 ± 1.0 | 2.4 ± 1.0 | 3.0 ± 1.0 | 3.1 ± 0.4 | 3.7 ± 1.1 | 2.8 ± 1.2 |
LipMM09‡ | 16.7 ± 9.7 | 7.0 ± 2.6** | 11.4 ± 5.2 | 14.5 ± 6.8 | 4.4 ± 1.6** | 12.5 ± 7.5 | 12.0 ± 5.4 | 12.3 ± 7.2 |
LipMM13‡ | 64.3 ± 73.2 | 15.9 ± 13.4* | 21.8 ± 16.1 | 49.6 ± 31.4 | 8.3 ± 2.4**** | 61.8 ± 73.9 | 63.4 ± 53.9 | 40.6 ± 47.9 |
[NAA]/[tCho] | 0.2 ± 0.2*** | 0.9 ± 0.9 | 0.9 ± 0.4** | 0.1 ± 0.2*** | 1.3 ± 0.5 | 0.1 ± 0.0***** | 0.6 ± 0.5 | 0.6 ± 0.6 |
[Crl]/[tCho] | 1.0 ± 0.4 | 2.1 ± 1.2 | 0.5 ± 0.3***** | 1.8 ± 0.8 | 0.7 ± 0.3 | 0.3 ± 0.2*** | 1.5 ± 0.5 | 1.1 ± 0.8 |
[mI]/[tCho] | 1.5 ± 0.9** | 4.0 ± 2.0 | 1.8 ± 0.7* | 4.8 ± 2.4 | 11.9 ± 3.7 | 0.9 ± 0.6* | 2.5 ± 1.1 | 3.0 ± 2.8 |
[Gln]/[tCho] | 1.2 ± 0.6**** | 2.8 ± 1.0 | 3.2 ± 1.7 | 2.9 ± 1.6 | 1.5 ± 0.5 | 0.7 ± 0.6 | 2.0 ± 1.2 | 2.3 ± 1.5 |
[Glu]/[tcho] | 1.5 ± 0.8 | 1.8 ± 1.7 | 1.7 ± 0.9 | 1.3 ± 1.5 | 2.3 ± 1.0 | 0.6 ± 0.3* | 4.0 ± 1.1* | 1.8 ± 1.4 |
[Glx]/[tCho] | 2.8 ± 0.9*** | 4.7 ± 2.2 | 4.8 ± 1.7 | 4.2 ± 2.6 | 3.8 ± 0.5 | 1.2 ± 0.7* | 6.0 ± 0.8** | 4.1 ± 2.0 |
[Tau]/[tCho] | 1.2 ± 0.5** | 0.3 ± 0.3 | 0.2 ± 0.4* | 0.5 ± 0.3 | 0.5 ± 0.6 | 0.6 ± 0.3 | 1.4 ± 0.6 | 0.6 ± 0.6 |
[NAA]/[Cr] | 0.2 ± 0.2** | 0.4 ± 0.3 | 1.8 ± 1.2** | 0.1 ± 0.1**** | 1.8 ± 0.4 | 0.1 ± 0.1*** | 0.4 ± 0.3* | 0.7 ± 1.0 |
[mI]/[Cr] | 1.7 ± 0.9* | 2.0 ± 0.5* | 3.6 ± 1.9 | 2.8 ± 1.4 | 16.6 ± 6.6 | 7.0 ± 7.3 | 1.8 ± 0.5* | 3.5 ± 4.0 |
[Gln]/[Cr] | 1.3 ± 0.7*** | 1.8 ± 1.0 | 5.5 ± 2.5*** | 1.7 ±0.7 | 2.0 ± 1.2 | 4.1 ± 4.0 | 1.3 ± 1.0 | 2.7 ± 2.4 |
[Glu]/[Cr] | 1.9 ± 1.5 | 0.8 ± 0.5*** | 3.5 ± 2.5 | 0.8 ± 1.0* | 3.1 ± 0.4 | 2.7 ± 1.0 | 2.9 ± 0.9 | 2.2 ± 1.8 |
[Glx]/[Cr] | 3.3 ± 1.6 | 2.6 ± 1.1* | 9.1 ± 4.6** | 2.5 ± 1.4* | 5.1 ± 1.1 | 7.0 ± 4.8 | 4.2 ± 1.1 | 4.9 ± 3.8 |
[Tau]/[Cr] | 1.3 ± 0.4* | 0.2 ± 0.3* | 0.3 ± 0.4* | 0.3 ± 0.3 | 0.5 ± 0.9 | 3.6 ± 2.8 | 1.2 ± 0.8 | 0.8 ± 1.1 |
[Gau]/[Cr] | 0.9 ± 0.4 | 0.3 ± 0.1**** | 2.7 ± 2.3 | 0.6 ± 0.3* | 2.4 ± 0.9 | 5.1 ± 4.3 | 1.4 ± 0.5 | 1.6 ± 1.9 |
[Glc]/[Cr] | 0.2 ± 0.2* | 0.4 ± 0.2 | 2.4 ± 1.5 | 0.2 ± 0.2* | 1.5 ± 1.3 | 6.5 ± 7.9 | 0.3 ± 0.3 | 1.2 ± 2.3 |
Note:—
P < .01,
P < .001,
P < .0001,
P < .00001,
P< .000001 versus All Other tumors
[Glx] = [Glu] + [Gln].
Absolute intensity (arbitrary units).