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. Author manuscript; available in PMC: 2021 Mar 19.
Published in final edited form as: ACS Chem Neurosci. 2021 Feb 2;12(4):735–745. doi: 10.1021/acschemneuro.0c00765

Figure 5.

Figure 5.

Haloperidol treatment inhibits DHCR7 enzyme in neurons and astrocytes. Cortical neuronal and astrocytes cultures were treated with haloperidol (10–500 nM). Fourteen sterols were analyzed by the DMG method. The data are presented to coincide with the sterol biosynthesis scheme presented in Figure 1. The scale for 7-DHD, Des, 7-DHC, and Chol is 0–40 nmol/million cells. The scale of all other sterols shown is 0–3.5 nmol/million cells. Statistical significance between neurons and astrocytes is shown in black, and significance between control and treatment is shown in blue for neurons and in red for astrocytes: *p < 0.05; **p < 0.01; ***p < 0.001.