Table 3.
S-type specific virulence factor genes
| Cluster | Predicted function | Ortholog virulence factor | Database | Reference | Identity (%) | Note |
|---|---|---|---|---|---|---|
| 31 | Nonribosomal peptide synthetase, partial [WP_019730007.1] | VFG009488(gi:41408271) (mbtE) MbtE [Mycobactin (CVF315)] | VFDB | Mycobacterium avium subsp. paratuberculosis K-10 | 99.2 | Only in S |
| 442 | GMC family oxidoreductase [WP_003874392.1] | fig|83332.12.peg.3806|Rv3409c|VBIMycTub87468_3806| Cholesterol oxidase (EC 1.1.3.6) @ Steroid Delta(5)→Delta(4)-isomerase (EC 5.3.3.1) | PATRIC | Mycobacterium tuberculosis H37Rv | 87.2 | Only in S |
| 510 | AMP-binding protein [WP_003875986.1] | VFG009545(gi:118462251) (mbtA) 2,3-dihydroxybenzoate-AMP ligase [Mycobactin (CVF315)] | VFDB | Mycobacterium avium 104 | 99.3 | Only in S |
| 1170 | Glycosyltransferase [WP_003876129.1] | VFG029573(gi:118465574) (gtf1) glycosyl transferase [GPL locus (CVF650)] | VFDB | Mycobacterium avium 104 | 98.6 | Only in S |
| 1221 | Glycosyltransferase [WP_003876135.1] | VFG029631(gi:118466342) (gtf2) glycosyltransferase 28 [GPL locus (CVF650)] | VFDB | Mycobacterium avium 104 | 98.8 | Only in S |
| 1841 | NAD-dependent epimerase/dehydratase family protein [WP_016706194.1] | VFG029546(gi:118464065) (rmlB) NAD dependent epimerase/dehydratase [GPL locus (CVF650)] | VFDB | Mycobacterium avium 104 | 99.7 | Only in S |
| 2721 | Class I SAM-dependent methyltransferase [WP_031350157.1] | VFG029564(gi:387876472) (rmt4) macrocin-O-methyltransferase [GPL locus (CVF650)] | VFDB | Mycobacterium intracellulare str. MOTT36Y | 90.5 | Only in S |
| 2849 | Class I SAM-dependent methyltransferase [WP_029245480.1] | VFG029626(gi:523914475) (rmt3) MtfD protein [GPL locus (CVF650)] | VFDB | Mycobacterium yongonense 05-1390 | 92.9 | Only in S |
| 2857 | Class I SAM-dependent methyltransferase [WP_009977502.1] | VFG029564(gi:387876472) (rmt4) macrocin-O-methyltransferase [GPL locus (CVF650)] | VFDB | Mycobacterium intracellulare str. MOTT36Y | 85.5 | Only in S |
| 5731 | Acyl carrier protein [WP_019306489.1] | VFG021806(gi:118462750) (MAV_2873) acyl carrier protein [Mycobactin (CVF315)] | VFDB | Mycobacterium avium 104 | 97 | Only in S |
| 23 | MbtE [AAS04490.1] | VFG009488(gi:41408271) (mbtE) MbtE [Mycobactin (CVF315)] | VFDB | Mycobacterium avium subsp. paratuberculosis K-10 | 100 | Not in S |
| 1384 | AMP-binding protein [WP_003875986.1] | VFG009544(gi:41408276) (mbtA) MbtA [Mycobactin (CVF315)] | VFDB | Mycobacterium avium subsp. paratuberculosis K-10 | 100 | Not in S |