Comparison of postmortem MR images and histologic findings in a 63-year-old subject. Postmortem axial (A) and coronal (B) T2-weighted images. Sections corresponding to B are stained with Klüver-Barrera (C), Berlin blue (D), and ferritin immunohistochemistry (E). Postmortem MR images (A and B) show present HPR. With Klüver-Barrera staining (C), HPR on a T2-weighed FSE image corresponds to the lateral marginal area of the putamen (dotted lines), where myelinated fibers are small in number in comparison with the remainder of the putamen. With Berlin blue staining (D), hemosiderin-stained blue is scattered in the inner portion of the putamen but is scarce in the lateral marginal area. With ferritin immunohistochemistry (E), ferritin deposits are mild in the lateral marginal area of the putamen (dotted lines), corresponding to HPR on the postmortem MR images (B). By contrast, the deposits are increased in the remainder of the putamen corresponding to the area of decreased signal intensity on the postmortem MR images (B).