Table 5. Associations of factors and post treatment survival in univariable and multivariable cox regression analyses.
| Risk Factor | Univariate | Multivariate | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | |
| Age >75 | 1.451 (0.628–3.349) | 0.384 | 1.216 (0.511–2.897) | 0.659 |
| Male | 1.345 (0.583–3.104) | 0.487 | 1.931 (0.767–4.864) | 0.163 |
| Cirrhosis | 4.009 (1.347–11.93) | 0.013 | 4.329 (1.252–14.973) | 0.021 |
| Cancer | 2.684 (1.122–6.424) | 0.027 | 2.368 (0.938–5.982 ) | 0.068 |
| DM | 0.867 (0.293–2.566) | 0.797 | 1.131 (0.303–4.222) | 0.855 |
| HTN | 0.729 (0.285–1.866) | 0.51 | 0.679 (0.225–2.044 ) | 0.491 |
| ASCITES | 5.383 (1.589–18.236) | 0.007 | 1.911 (0.457–7.997) | 0.375 |
| FIB4, | 1.048 (0.996–1.103) | 0.072 | – | – |
| HCV RNA, log10 IU/mL | 0.767 (0.532–1.105) | 0.154 | – | – |
| Comorbidity number*a | 1.691 (0.53–5.389) | 0.375 | – | – |
| BMI, kg/m2 | 0.986 (0.887–1.097) | 0.800 | – | – |
| CRE, mg/dL | 1.169 (1.045–1.308) | 0.006 | 1.205 (1.054–1.378) | 0.006 |
| eGFR, mL/min/1.73m2 | 0.984 (0.97–0.998) | 0.021 | – | – |
| ALT, U/L | 0.997 (0.988–1.007) | 0.586 | – | – |
| INR | 1.056 (0.455–2.451) | 0.899 | – | – |
| BIL, mg/dL | 1.143 (0.845–1.548) | 0.386 | – | – |
| ALB, g/dL | 0.167 (0.079–0.356) | <0.001 | 0.173 (0.065–0.466) | 0.001 |
| HB, g/dL | 0.775 (0.642–0.936) | 0.008 | – | – |
Notes.
- BMI
- body mass index
- ALT
- alanine aminotransferase
- BIL
- bilirubin
- ALB
- albumin
- CRE
- Creatinine
- INR
- international normalized ratio
- HB
- haemoglobin
- FIB-4
- Fibrosis-4
- DM
- diabetes mellitus
- HTN
- hypertension
- HCV
- hepatitis C virus
- eGFR
- estimated Glomerular filtration rate
a
Comorbidity number*: CHB, CHD, HIV, and CVA, excluding Cirrhosis, CANCER, DM, and HTN