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A, Bone marrow hematoxylin-eosin (H&E) 1000× (oil), bone marrow in CLL, shows replacement of normal marrow elements by sheets of small mature lymphocytes (arrows). B, Brain H&E 1000× (oil), large cell non-Hodgkin lymphoma (Richter) transformation of CLL. Note nucleoli (arrows) and mitotic figures (arrowheads).
