Table 3:

Gray-matter volume loss in patients with ALS compared to healthy subjects (P < .001, uncorrected)

Anatomical Location	Cluster Size k	MNI Coordinates* (mm)			Z-Score
		x	y	z
Right temporal lobe
Subgyral	439	42	−13	−23	3.80
Superior temporal gyrus-uncus	75	33	8	−27	3.24
Middle temporal gyrus	366	58	5	−26	3.33
Parahippocampal gyrus	1047	32	−11	−9	3.53
Middle temporal gyrus	186	61	−5	−14	3.55
Left temporal lobe
Middle temporal gyrus	200	−58	3	−21	3.33
Subgyral	1464	−36	−4	−17	3.84
Right frontal lobe
Inferior frontal gyrus	292	43	23	−14	3.31
Inferior frontal gyrus	197	29	19	−9	3.34
Extranuclear insula	704	33	−1	22	4.01
Superior frontal gyrus	81	39	57	32	3.41
Left frontal lobe
Inferior frontal gyrus	112	−40	23	−13	3.36
Insula	147	−31	4	15	3.39

^*The coordinates refer to the Montreal Neurological Institute (MNI) space and denote the areas of maximal gray matter volume loss within each cluster.