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. 2021 Mar 5;8:586875. doi: 10.3389/fmed.2021.586875

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Copyright © 2021 Levast, Benech, Gasc, Batailler, Senneville, Lustig, Pouderoux, Boutoille, Boucinha, Dauchy, Zeller, Maynard, Cazanave, Le Thi, Josse, Doré, Laurent and Ferry.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of antibiotics on the gut microbiota in bone joint infection (BJI). (A) Shannon index (genus level) at three times of sampling; Wilcoxon test. (B) Richness (genus level) at three times of sampling; Wilcoxon test. (C) Shannon index at three times of sampling according to the type of BJI; Wilcoxon test for paired comparison, Mann–Whitney analysis for inter-group comparisons. (D) Global composition of bacterial microbiota at the phylum level. (E) Beta diversity. Principal coordinate analysis of Bray–Curtis distance at three different times of sampling; permutational multivariate analysis of variance. B, baseline; EOT, end of treatment; FU, follow-up. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.