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Brain-targeted delivery of US-HA-Exo combined with FUS-mediated BBB opening. (A, B) Schematic of FUS-BBB opening-assisted delivery of exosomes. (C) Brain sections obtained from 10-month-old APP/PS1 mice were immuno-stained for Aβ, scale bar: 100 µm. (D) The percentage area of positive amyloid-β stainning was quantified. (E, F) Aβ plaques in the brain were detected by thioflavin-S staining (scale bar: 100 µm), and quantified. (G) H&E staining of major organs of mice, scale bar: 100 µm.
