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. 2021 Feb 25;11(9):4281–4297. doi: 10.7150/thno.51193

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Antitumor effect of Ze-IR700-mediated PDT in mice bearing tumor grafts of CRC cells. A. Preparation of Ze-IR700 by conjugating the photosensor IR700 to Ze affibody. B. Binding of Ze-IR700 to LS174T and HT29 cells. C. Accumulation of Ze-IR700 in the lysosomes of LS174T cells. D. ROS produced in LS174T cells treated with Ze-IR700- or trypsinized Ze-IR700 (Ze-IR700-TN)-mediated PDT. E. Death of LS174T and HT29 cells treated with Ze-IR700- or Ze-IR700-TN-mediated PDT. F. Tumor growth suppression by Ze-IR700-mediated PDT. Mice (N=5) bearing LS174T or HT29 tumor grafts were intravenously injected with 1 mg/kg (Ze-IR700-1) or 3 mg/kg (Ze-IR700-3) Ze-IR700 followed by irradiation 4 h later.