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. 2021 Feb 25;11(9):4281–4297. doi: 10.7150/thno.51193

Figure 4.

Figure 4

Ze-IR700-mediated PDT upregulated TRAIL receptors and exerted synergistic cytotoxicity with TRAIL proteins in LS174T cells. A,B,C. Expression profiles of pro-apototic genes (A), anti-apoptotic genes (B), and death receptors and decoy receptors (C) in LS174T cells treated with or without PDT. D. Flow cytometry analysis of DR4 and DR5 in LS174T cells treated with or without PDT. E. Cytotoxicity of TRAIL proteins in LS174T cells treated with or without PDT. F. Expression profile of DR4 and DR5 in tumor tissues treated with or without PDT. The tumor tissues collected before PDT (PDT-0) or at 2 h post-PDT (PDT-120) were frozenly sectioned and stained with antibody against DR4 or DR5. Tumor microvessels were illustrated by CD31 staining. The nuclei were visualized by DAPI staining.