Figure 5.

Ze-IR700-mediated PDT increased tumor uptake and apoptosis induction of TRAIL proteins in LS174T tumor grafts. A. Uptake of TRAIL proteins by tumor grafts treated with or without PDT. B. Apoptosis induction of TRAIL proteins in tumor grafts treated with or without PDT. The tumor tissues were collected 24 h after treatment, and the apoptotic cells were visualized by TUNEL staining. The nuclei were illustrated by DAPI staining. The apoptotic rate was expressed as the ratio of TUNEL-positive cells (apoptotic cells) to the DAPI-positive cells (total cells). C. Histology of tumor grafts treated with monotherapy or combination therapy of TRAIL proteins and PDT. The tumor tissues were collected 24 h after treatment and stained with H&E.