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. 2021 Mar 4;11(9):4421–4435. doi: 10.7150/thno.53901

Figure 1.

Figure 1

The expression of CK1δ or CK1ε is inversely correlated with AES expression in human CRC specimens. (A-C) The mRNA expression of CK1ε (A), CK1δ (B) and AES (C) in colon adenocarcinomas and non-malignant adjacent colon tissues using data from the Cancer Genome Atlas (TCGA) database. (D) Representative images of IHC staining to detect the expression of AES, CK1δ and CK1ε in CRC specimens. Scale bar, 50 μm. (E) The expression of AES was inversely related to CK1δ levels in CRC specimens (P < 0.05, χ2 tests). CK1δ and AES expression was detected by IHC staining in CRC specimens. The IHC staining for AES and CK1δ was scored as high or low based on their IHC expression levels. (F) Similar to (E) except that CK1ε expression was detected. The expression of AES was inversely related to CK1ε levels in CRC specimens (P < 0.05, χ2 tests). (G) The expression of AES, CK1δ and CK1ε in normal colon epithelial cell (CCD 841 CoN) and colon cancer cells (HCT116, SW480, HT29) were detected by WB.