Table 2.
The specific molecular mechanisms and biological functions of m6A modification on ncRNAs
| Categories | m6A-related enzymes | Non-coding RNAs | Mechanisms | Biological functions | References |
|---|---|---|---|---|---|
| m6A-miRNA | METTL3 | miR-221/222 | Promoting miR-221/222 maturation. | Accelerating cell proliferation of bladder cancer. | 110 |
| METTL3 | miR-1246 | Facilitating miR-1246 maturation. | Promoting the metastasis of colorectal cancer. | 111 | |
| METTL3 | miR-873-5p | Strengthening miR-873-5p maturation. | Blocking oxidative stress and apoptosis in colistin-evoked nephrotoxicity. | 112 | |
| METTL3 | miR-143-3p | Enhancing miR-143-3p maturation. | Facilitating angiogenesis and brain metastasis of lung cancer. | 113 | |
| METTL3 | miR-320 | Increasing the m6A level of pre-miR-320. | Driving osteogenic differentiation of bone marrow-derived mesenchymal stem cells. | 114 | |
| METTL3 | miR-7212-5p | Mediating miR-7212‐5p maturation. | Inhibiting osteoblast differentiation and fracture healing. | 115 | |
| METTL3, NKAP | miR-25-3p | Accelerating miR-25-3p maturation. | Promoting the progression of pancreatic cancer. | 66 | |
| METTL14 | miR-126 | Inducing miR-126 maturation. | Suppressing hepatocellular carcinoma metastasis. | 117 | |
| m6A-lncRNA | METTL3, YTHDF3 | MALAT1 | Enhancing the stability of MALAT1. | Inducing drug resistance and metastasis of non-small cell lung cancer. | 128 |
| WTAP | XIST | Co-localizing with XIST. | Participating in XIST-mediated silencing. | 130 | |
| METTL3, WTAP, RBM15/15B, YTHDC1 | XIST | Promoting XIST-mediated transcriptional repression. | / | 28 | |
| METTL14, YTHDF2 | XIST | Abolishing the stability of XIST. | Suppressing proliferation and metastasis of colorectal cancer. | 133 | |
| METTL3 | LINC00958 | Promoting the stability of LINC00958. | Increasing the lipogenesis of hepatocellular carcinoma. | 135 | |
| METTL3, METTL14 | LNCAROD | Up-regulating the expression of LNCAROD. | Facilitating the progression of head and neck squamous cell carcinoma. | 136 | |
| VIRMA | CCA1/2 | Increasing the m6A level of CCA1/2. | Inducing aggressive phenotype of prostate cancer. | 137 | |
| IGF2BP2 | DANCR | Strengthening the stability of DANCR. | Enhancing stemness-like properties of pancreatic cancer. | 52 | |
| ALKBH5, YTHDF2 | PVT1 | Elevating PVT1 expression. | Promoting the tumorigenesis of osteosarcoma. | 138 | |
| METTL3 | RHPN1-AS1 | Enhancing RHPN1-AS1 expression. | Accelerating the proliferation and metastasis of epithelial ovarian cancer. | 139 | |
| METTL3, ALKBH5, hnRNPA2B1 | RP11 | Increasing the expression of RP11. | Triggering the metastasis of colorectal cancer. | 140 | |
| YTHDF3 | GAS5 | Promoting the decay of GAS5. | Inhibiting the tumorigenesis of colorectal cancer | 141 | |
| METTL3, METTL14, WTAP, ALKBH5, YTHDF1 | LINC00278 | Modulating the m6A modification of LINC00278 and then affecting YY1BM translation. | Regulating the progression of cigarette smoking-related esophageal squamous cell carcinoma. | 65 | |
| METTL3, YTHDC1 | pncRNA-D | Methylating pncRNA-D and inhibiting its binding to TLS. | Modulating cell cycle. | 142 | |
| METTL3 | linc1281 | Sustaining the interaction of linc1281 and pluripotency-related miRNAs. | Affecting the differentiation potential of embryonic stem cells. | 143 | |
| YTHDF2 | lnc-Dpf3 | Inducing the degradation of lnc-Dpf3. | Controlling the migration of dendritic cells. | 144 | |
| m6A-circRNA | YTHDC1 | circNSUN2 | Recognizing circNSUN2 to enhance its cytoplasmic transport. | Facilitating colorectal carcinoma liver metastasis. | 156 |
| METTL3, YTHDC1, YTHDF3 | circ-ZNF609 | Promoting circZNF609 translation. | / | 158 |