Table 3.
The underlying molecular mechanisms and biological functions of ncRNAs on m6A modification
| Categories | Non-coding RNAs | m6A-related enzymes | Mechanisms | Biological functions | References |
|---|---|---|---|---|---|
| miRNA-m6A | miR-145 | YTHDF2 | Inhibiting the expression of YTHDF2. | / | 121 |
| miR-186 | METTL3 | Suppressing METTL3 expression. | Inhibiting the growth and metastasis of hepatoblastoma | 122 | |
| let-7g | METTL3 | Attenuating the expression of METTL3. | Accelerating the progression of breast cancer. | 123 | |
| lncRNA-m6A | LINRIS | IGF2BP2 | Maintaining the stability of IGF2BP2. | Promoting the aerobic glycolysis in colorectal cancer. | 145 |
| ARHGAP5-AS1 | METTL3 | Recruiting METTL3 to methylate and stabilize ARHGAP5. | Strengthening the chemoresistance of gastric cancer. | 146 | |
| GAS5-AS1 | ALKBH5 | Interacting with ALKBH5 to demethylate and stabilize GAS5. | Suppressing the growth and metastasis of cervical cancer. | 147 | |
| FOXM1-AS | ALKBH5 | Increasing the binding of ALKBH5 to FOXM1 pre-mRNA. | Facilitating the tumorigenicity of glioblastoma stem-like cells. | 116 | |
| GATA3-AS | KIAA1429 | Enhancing the interaction between KIAA1429 and GATA3 pre-mRNA. | Accelerating hepatocellular carcinoma progression. | 149 | |
| LINC00266-1 | IGF2BP1 | Promoting the recognition of IGF2BP1 upon m6A-modified RNAs like c-Myc. | Strengthening tumorigenesis of colorectal cancer. | 150 | |
| circRNA-m6A | circSTAG1 | ALKBH5 | Capturing ALKBH5 and reducing its intranuclear translocation. | Attenuating the depressive-like behaviors. | 163 |