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. 2021 Mar 4;11(9):4403–4420. doi: 10.7150/thno.53737

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Methylation analysis of the epiallele in SLC16A5 and immunohistochemistry analysis of SLC16A5. (A) UCSC browser visualization of the positions of cg15190451 and its corresponding epiallele chr17:73090153-73090195. (B) The boxplot of methylation level of cg15190451 in hypoxic cluster and normoxic cluster for TCGA BRCA samples (Wilcoxon test, p=3.778e-16). (C) The methylation level and methylation patterns of the epiallele in tumor core (C1) and tumor periphery (P3, P6, P9 and P12). (D) Immunohistochemistry images of breast tumor (T) and adjacent normal breast tissue samples (N). Significantly darker brown staining of SLC16A5 protein was detected in cancer tissues than in adjacent normal tissues. The percentage of breast tissues with high SLC16A5 expression was significantly greater than that of normal tissues, **p < 0.01 by chi-square test. (E) Immunohistochemistry images of SLC16A5-high expression samples (H) and SLC16A5-low expression samples (L). * p < 0.05, **p < 0.01 by chi-square test. (F) Kaplan-Meier curves of OS and PFS based on HER2-positive breast cancer patients.