Figure 3.

Longitudinal monitoring of the mean cerebral blood flow by FAIR-MRI 1, 3, 7, 14, 21 and 30 days after stroke. CBF was assessed within the infarct defined on the T₂w-MR images from day 1 post ischemia and this mirrored ROI in the contralateral side in control (green) and HT-fed (red) mice. (A) Representative CBF images at days 1, 3, 7, 14, 21 and 30 post ischemia for both control (upper row) and HT-fed mice (lower row) and the corresponding T₂w-MR image at day 1 post ischemia. CBF maps showed hypoperfused infarct regions within the first week for both groups. At later time points, CBF was partially recovered in both groups. (B) Quantification of the mean CBF within the infarct and contralateral striatum showed no treatment effect on tissue reperfusion. Values represent mean ± sd (n = 8 per group). Statistical analysis was carried out with RM ANOVA followed by Holm Sidak's post hoc test for multiple comparisons (# p < 0.05, ## p < 0.01, ### p < 0.005, # vs. contralateral).