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. 2021 Feb 19;11(9):4078–4089. doi: 10.7150/thno.52574

Figure 3.

Figure 3

EA stimulation activated the α7nAChR-mediated JAK2/STAT3 pathway in macrophages. The level of JAK2 and STAT3 in intestinal muscularis was evaluated by Western blot (A) or immunofluorescence staining (B, C). × 100 magnification. The frequencies JAK2+ macrophages or newly recruited macrophages (D, E). The expression of JAK2 was evaluated by Western blot with α7nAChR antagonist MLA and α-BGT (F). The mean gastrointestinal transit was evaluated in each group (G). The expression of serum IL-6 (H) and TNF-α (I) was analyzed by ELISA. &p < 0.05 versus Sham group, *p < 0.05 versus IM group, Δp < 0.05 versus IM + Non-acu group, #p < 0.05 versus IM + DMSO + EA group.