Table 2.
Echocardiographic Parameters of Streptozotocin-induced Diabetic Mice
| IVS, mm | LVEDD, mm | LVESD, mm | LVPWd, mm | FS,% | EF,% | |
|---|---|---|---|---|---|---|
| Control 12 w | ||||||
| KLK8+/+ | 0.73 ± 0.05 | 2.12 ± 0.09 | 1.13 ± 0.09 | 0.93 ± 0.06 | 50.73 ± 2.63 | 68.55 ± 2.57 |
| KLK8-/- | 0.81 ± 0.04 | 2.11 ± 0.08 | 1.15±0.06 | 1.05 ± 0.07 | 49.22 ± 2.26 | 68.98 ± 3.79 |
| Diabetes 12 w | ||||||
| KLK8+/+ | 0.77 ± 0.04 | 2.16 ± 0.11 | 1.10 ± 0.06 | 1.05 ± 0.06 | 48.20 ± 1.34 | 66.61 ± 2.27 |
| KLK8-/- | 0.75 ± 0.03 | 2.16 ± 0.08 | 1.19 ± 0.08 | 1.01 ± 0.09 | 51.37 ± 3.61 | 69.39 ± 3.46 |
| Control 24 w | ||||||
| KLK8+/+ | 0.81 ± 0.03 | 2.26 ± 0.10 | 1.30 ± 0.05 | 1.11 ± 0.08 | 50.76 ± 1.90 | 70.05 ± 1.87 |
| KLK8-/- | 0.77 ± 0.04 | 2.30 ± 0.09 | 1.31 ± 0.04 | 1.10 ± 0.06 | 49.65 ± 2.41 | 71.34 ± 3.19 |
| Diabetes 24 w | ||||||
| KLK8+/+ | 0.77 ± 0.03 | 2.86 ± 0.09**** | 1.69 ± 0.04**** | 1.18 ± 0.04 | 38.88 ± 1.62** | 58.31 ± 1.54** |
| KLK8-/- | 0.78 ± 0.02 | 2.53 ± 0.06# | 1.41 ± 0.03## | 1.06 ± 0.05 | 46.39 ± 1.14# | 67.99 ± 1.30# |
IVS indicates interventricular septum thickness; LVEDD, left ventricular end-diastolic dimension; LVESD, left ventricular end-systolic dimension; LVPWd, left ventricular diastolic posterior wall thickness; FS, fractional shortening; and EF, ejection fraction. Data are expressed as mean ± SEM (n = 7~8). **p < 0.01, ****p < 0.0001 versus KLK8+/+ control obtained after 24 weeks; #p < 0.05, ##p < 0.01 versus KLK8+/+ after 24 weeks of diabetes.