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. 2021 Feb 20;11(9):4187–4206. doi: 10.7150/thno.49054

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Conditional knockout SARM1 in astrocytes also improved the functional recovery of mice after SCI. (A) Representative footprint images of 2 M male SARM1^f/f and SARM1^GFAP-CKO mice at 3 d and 14 d after SCI. (B-C) Quantitative analysis of stride length (B) and stride width (C) in footprint assays of 2 M male SARM1^f/f and SARM1^GFAP-CKO mice as shown in (A) (n = 6 per group). (D) Quantitative analysis of gross voluntary movement in open-field test of 2 M male SARM1^f/f and SARM1^GFAP-CKO mice at 3 d and 14 d after SCI (n = 20 per group). (E) Quantitative analysis of BMS scoring of 2 M male SARM1^f/f and SARM1^GFAP-CKO mice at 3 d and 14 d after SCI (n = 20 per group). (F) Immunostaining analysis of NF (red) in the spinal cords of SARM1^f/f and SARM1^GFAP-CKO mice at 28 d after SCI. Dashed lines indicated the outline of the injury sites. Images of selected regions (rectangles) in (F) were shown at higher magnification. Scale bars, 1cm (A), 20 µm (E). Data were mean ± SEM. Two-tailed Student's t-test, ^***P < 0.001.