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. 2021 Mar 19;22:196. doi: 10.1186/s12864-021-07507-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Expression level distributions of the accepted microRNAs and differentially expressed microRNAs. a. Median normalized expression levels of all the microRNAs after normalized and filtered in each group and the DE microRNAs in each group. “All DEGs in AL” shows the expression levels in AL group of the microRNAs differentially expressed in CR, EX or HF. In each group, the top 25% accepted microRNAs were taken as high abundant genes, the bottom 25% as low abundant genes and the middle 50% as medium abundant genes. Those with Foreground-Background intensities < 50 were taken as very low abundant genes. Line in scatter dot plot is at median with interquartile range. b-d. The DE microRNAs median normalized expression levels in the two compared groups. AL: ad libitum, CR: caloric restriction, EX: exercise, HF: high-fat diet, DEG: differentially expressed microRNA genes, Up: up-regulated microRNAs, Down: down-regulated microRNAs