Table 1.
The top 10 enriched GO terms and KEGG pathways
| Group | GO terms | KEGG pathways | ||
|---|---|---|---|---|
| BP | CC | MF | ||
| Common in CR, EX and HF |
oxidation-reduction process; lipid metabolic process; metabolic process; fatty acid metabolic process; blood coagulation; hemostasis; steroid metabolic process; lipid homeostasis |
intracellular membrane-bounded organelle; extracellular exosome; mitochondrion; endoplasmic reticulum; blood microparticle; peroxisome; membrane; extracellular region |
oxidoreductase activity; catalytic activity; monooxygenase activity; flavin adenine dinucleotide binding; iron ion binding; oxidoreductase activity (acting on paired donors, with incorporation or reduction of molecular oxygen) |
Metabolic pathways; PPAR signaling pathway; Fatty acid degradation; Complement and coagulation cascades; Biosynthesis of antibiotics; Retinol metabolism; Chemical carcinogenesis |
| Common in CR and EX | triglyceride metabolic process | – | – | – |
| Common in CR and HF | – | cytosol |
transferase activity; hydrolase activity |
– |
| Common in EX and HF | – | mitochondrial inner membrane | heme binding |
Tryptophan metabolism; Valine, leucine and isoleucine degradation |
| Only in CR | fatty acid beta-oxidation | extracellular space |
fatty-acyl-CoA binding; oxidoreductase activity (acting on the CH-CH group of donors) |
Ascorbate and aldarate metabolism; Butanoate metabolism; Fatty acid metabolism |
| Only in EX | xenobiotic metabolic process | cytoplasm |
lyase activity; metal ion binding; pyridoxal phosphate binding |
Steroid hormone biosynthesis |
| Only in HF |
cholesterol homeostasis, steroid biosynthetic process |
– | protein homodimerization activity | Peroxisome |