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. Author manuscript; available in PMC: 2022 Jan 15.
Published in final edited form as: J Immunol. 2021 Jan 15;206(2):302–309. doi: 10.4049/jimmunol.2000905

Figure 3. Immune-stromal circuits in the skin that may contribute to photosensitivity.

Figure 3.

Protective circuits are denoted by blue arrows, pathogenic circuits by red arrows, and circuits that can have dual roles by purple arrows. (A) Langerhans cell-keratinocyte circuit. (B) Monocyte-epidermal circuit. (C) a. keratinocyte-neutrophil circuit; b. neutrophil-endothelial cell circuit; c. neutrophil-immune cell circuit. (D) IFN-I circuits involving IFN-I originating from a. immune cells and b. stromal cells. (E) cGAMP originating from skin for systemic signal transmission. (F) Lymphatic flow and function that connects skin to draining lymph nodes and systemic circulation. (G) Neuronal control of immunity. (H) Migration of skin-derived Langerhans cells and dendritic cells connects skin events to draining lymph nodes. See text for details.