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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Nat Microbiol. 2020 Oct 19;5(12):1576–1587. doi: 10.1038/s41564-020-00795-7

Extended Data Fig. 7. The inhibition of the SQSTM1-INSR pathway protects mice against LPS-induced endotoxemia.

Extended Data Fig. 7.

(a) Administration of anti-SQSTM1 monoclonal antibodies (20 mg/kg) or depletion of INSR in myeloid cells in mice prevented LPS (10 mg/kg)-induced animal death (n = 10 mice/group; Log-rank test). (b-k) In parallel, the serum levels of CK (b), AMY (c), BUN (d), GPT/ALT I (e), IL6 (f), IL1B (g), TNF (h), HMGB1 (i), LDH (j), and lactate (k) were assayed (n = 5 mice/group; two-tailed t test, versus control group). Data in (b-k) are presented as mean ± SD. Data in (a-k) are from two independent experiments.