Table 1.
Demographic and Clinical Characteristics
| Median (IQR) or n (%) | Normal Menarche n = 124* | Delayed Menarche n = 21** | p-value |
|---|---|---|---|
| Age at menarche (yrs) | 12.0 (12.0, 13.0) | 15.7 (15.0, 17.4) | <0.001 |
| African American | 15 (12.1%) | 6 (28.6%) | 0.047 |
| Abnormal birth history† | 45 (36.3%) | 9 (42.9%) | 0.621 |
| Food assistance | 13 (10.5%) | 1 (4.8%) | 0.406 |
| Kidney Disease Characteristics | |||
| Age at onset (yrs) | 0 (0, 3) | 0 (0, 9.5) | 0.672 |
| Duration of CKD at menarche (yrs)‡ | 12.0 (8.5, 13.0) | 15.0 (7.9, 16.3) | <0.001 |
| Glomerular diseas | 35 (28.2%) | 7 (33.3%) | 0.633 |
| eGFR at menarche (ml/min/1.73m2) | 47.8 (32.6, 64.0) | 30.6 (25.3, 37.1) | 0.007 |
| Growth hormone use ever | 12 (9,7%) | 4 (19.1%) | 0.205 |
| Corticosteroid use ever | 10 (8.1%) | 6 (28.6%) | 0.006 |
| Growth | |||
| Weight percentile at menarche‡ | 52.4 (24.3, 81.6) | 14.1 (2.8, 74.1) | 0.007 |
| Height percentile at menarche‡ | 32.8 (8.4, 65.8) | 10.4 (2.5, 26.3) | 0.003 |
| BMI at menarche‡ | 19.9 (18.2, 23.3) | 20.6 (17.5, 24.5) | 0.636 |
Footnotes
*
Girls with incident menarche at age ≤ 15
**
Includes 7 girls with incident menarche at age ≥ 15 and 14 girls who remained pre-menarchal at age ≥ 15 at last study visit
†
Premature (less than 32 weeks gestational age), low birth weight (less than 2500 grams), small for gestational age (less than 10th percentile)
‡
Demographic and clinical characteristics at the last study visit are used for the 14 pre-menarchal girls with delayed menarche as defined by pre-menarchal status at age ≥ 15