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Incidence of treatment-related SAEs and irAEs in key subgroups. (A) treatment-related SAEs and (B) treatment-related irAEs. The Clopper–Pearson method was used to calculate the 95% CI. aRenal impairment defined as estimated glomerular filtration rate <60 mL/min/1.73 m2. CNS, central nervous system; ECOG PS, Eastern Cooperative Oncology Group performance status; HBV/HCV, hepatitis B/C virus; irAE, immune-related adverse event; PD-1, programmed death-1; SAE, serious adverse event.
