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. 2021 Mar 4;11(10):4790–4808. doi: 10.7150/thno.57456

Figure 2.

Figure 2

DUSP5 siRNA+T3 therapy induces LV growth and LV chamber elongation in young adult (5-week-old) mice. (A) Diagram showing sites of LV dimension measurements using echocardiography. (B-G) Effect of T3 therapy in mice pretreated with either DUSP5 siRNA or DUSP 5 scrambled siRNA (control) on posterior wall (PW) dimensions at diastole at the LV mid-papillary (B) and mid-apical level (C) and at the LV apex (D), and LV chamber internal dimensions (LVID) at diastole at the LV mid-papillary (E) and mid-apical level (F) and LVID long axis (G). (H) LVID long-axis-to-mid-papillary ratio at diastole (n = 10 mice per group); *P < 0.05, **P < 0.01, ***P < 0.001. Individual data points are mean ± s.e.m are shown. Comparisons were made using ANOVA with Sidak multiple comparison test; only within group P-values are shown.