Figure 6.

Transient DUSP5 siRNA+T3 therapy increases cardiac muscle cell number in doxorubicin-injured hearts. (A) Schematic showing the experimental protocol used to create doxorubicin-induced cardiotoxicity and implementation of transient therapies with scrambled siRNA (control) or DUSP5 siRNA+T3 therapy. (B) Total ventricular cardiomyocyte numbers in doxorubicin-treated mice were determined 3-weeks after scrambled siRNA or DUSP5 siRNA+T3 therapy as well as in untreated age-matched controls (n = 6-7 mice per group). Individual data points and mean ± s.e.m are shown. ***P < 0.001, ns: not significant. Comparisons between groups were made using ANOVA with Sidak multiple comparison test.