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. 2021 Mar 4;11(10):4790–4808. doi: 10.7150/thno.57456

Figure 9.

Figure 9

Transient DUSP5 siRNA+T3 therapy reverses LV dysfunction in doxorubicin-injured hearts. (A) Diagram showing the experimental protocol used to create doxorubicin-induced cardiotoxicity and implementation of transient therapies with DUSP5 scrambled siRNA (control) or DUSP5 siRNA+T3 therapy. (B-E) Repeated assessments in mice of LV end-diastolic volume (EDV) (B), end-systolic volume (ESV) (C), LV ejection fraction (D) and LV stroke volume (E) at the end of repeated doxorubicin exposure (pre-therapy) and 1- and 3-week after scrambled siRNA or DUSP5 siRNA+T3 therapy (n = 13-14 mice/group). These temporal assessments were also made in age-matched controls that were not exposed to doxorubicin or any therapy (n = 15). ***P < 0.0001. Individual data points and mean ± s.e.m are shown. Comparisons with the doxorubicin+DUSP5 siRNA+T3 group were made using ANOVA with Sidak multiple comparison test. PT, post-therapy; DOX, doxorubicin; CM, cardiomyocyte.