Table 1.
Antioxidative phytochemicals in cancer prevention.
| Phytochemicals | Cell line/tumor model | Anti-cancer effects |
|---|---|---|
| Curcumin | Pancreatic cancer cells (BxPC3 and PANC1) | Suppresses cancer cell migration and invasion 218 |
| Breast cancer cells (MDA-MB-231, BT-483, and MCF7) | Suppresses cancer cell proliferation and invasion 219, 220 | |
| NSCLC cell line (A549 and H460) | Decreases in vitro metastatic progression and increased apoptosis 221, 222 | |
| Prostate cancer cells (PC12) | Inhibits cancer cell invasion 223 | |
| UV-induced skin injury model | Reduces UV-induced cytotoxicity 224 | |
| Dalton's lymphoma bearing mice | Reduces tumor invasiveness 225 | |
| BaP-induced forestomach tumorigenesis | Reduces tumor growth 226 | |
| EGCG | Mammary epithelial cells (MCF10A) | Enhances antioxidant defense capacity 227 |
| Liver cancer cells (HepG2) | Reduces exogenous oxidative stress 228 | |
| Orthotropic mouse model of colon cancer | Reduces primary tumor growth and its metastasis to liver and lungs 229 | |
| Carcinogen-induced mouse model of colon carcinogenesis | Protective role against colon carcinogenesis 179 | |
| Immortalized human keratinocyte (HaCaT) | Protects skin against ionizing-radiation against DNA damage 230 |
|
| Resveratrol | Mammary epithelial cells (MCF10A) | Protects against (4-OHE2)- induced migration and transformation 231 |
| Pancreatic cancer cells (BxPC3 and PANC1) | Inhibits ROS-induced proliferation and migration 232 | |
| Prostate cancer cells | Inhibits DHT-induced progression 233 | |
| Estrogen induced breast carcinogenesis | Protects from oxidative stress and its associated DNA damage 234, 235 | |
| Rat model of hepatocarcinogenesis | Suppresses oxidative stress 236 | |
| Hesperidin | Azoxymethane induced Liver carcinogenesis | Inhibits burden of Hepatic tumors 237 |
| NSCLC cell line (A549) | Suppresses migration and invasion in vitro 238 | |
| 2'-hydroxyflavanone | Renal cancer | Inhibits survival of cancer cells in vitro and tumors in vivo 239, 240 |
| Lung cancer cell lines | Inhibits growth in nude mouse xenograft models 241 | |
| Breast cancer | Inhibits cancer cell survival, cell cycle in vitro and tumor progression in vivo 242 | |
| Quercetin | Lung cancer | Suppresses metastasis 243 |
| Breast cancer | Incudes apoptosis and necroptosis 244 | |
| Liver cancer | Inhibits proliferation and induces apoptosis 245 |