Figure 5.

Comparison of the prognostic and predictive capacities between HPRS and traditional features. (A & B) Meta-analysis was performed to calculate the pooled HR of TNM staging classification or HPRS, respectively. (C & D) Kaplan-Meier analysis was used to plot survival curves and evaluate survival difference in the pooled cohort to visualize the prognostic values of staging classification and HPRS, respectively. (E & F) In both stage IA and stage IB subgroups, HPRS retained its prognostic capacity to discriminate high-risk subset with Z-score of zero as a cut-off value. (G) Multivariate Cox regression analysis was performed on four variables including HPRS, p-stage, gender and age in the pooled cohort. (H) C-index of HPRS ranks first among all the parameters. (I) DCA graphically illustrated that HPRS brought more net benefit of survival than other parameters at two different time points.